Animal Reproduction (AR)
https://www.animal-reproduction.org/article/doi/10.21451/1984-3143-AR2018-0076
Animal Reproduction (AR)
Conference Paper

From clinics to (cow)mics: a reproductive journey

Patrice Humblot

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Abstract

This manuscript describes the different topics I have been involved in the fields of reproductive physiology and embryo biotechnologies with attempts to address practical issues raised mainly by the breeding industry. The journey started with phenotyping work in the field of reproductive physio-pathology. Other issues were related to the optimization of reproductive biotechnologies to favorize genetic selection. The implementation of genomic selection raised opportunities to develop the use embryo biotechnologies and showed the interest of combining them in the case of embryo genotyping. There is still a need to refine phenotyping for reproductive traits especially for the identification of markers of uterine dysfunction. It is believed that new knowledge generated by combining different molecular approaches will be the source of applications that may benefit AI practice and embryo technologies.

Keywords

cattle, genomics, reproductive phenotypes, reproductive technologies.

References

Adnane M, Chapwanya A, Kaidi R, Meade KG, O'Farrelly C. 2017. Profiling inflammatory biomarkers in cervico-vaginal mucus (CVM) postpartum: Potential early indicators of bovine clinical endometritis? Theriogenology, 103:117-122.

Alm-Kristiansen AH, Gaustad ER, Bai G, Standerholen FB, Klinkenberg G, Kommisrud E, Waterhouse KE. 2018. In vitro studies of Norwegian Red bovine semen immobilized and cryopreserved in alginate solid gel network. Reprod Domest Anim, 53:365-370.

Angulo L, Guyader-Joly C, Auclair S, HennequetAntier C, Papillier P, Boussaha M, Fritz S, Hugot K, Moreews F, Ponsart C, Humblot P, Dalbies-Tran R. 2015. An integrated approach to bovine oocyte quality: from phenotype to genes. Reprod Fertil Dev, 18. doi: 10.1071/RD14353.

Association of Embryo Technology in Europe. 2016. Workshop report: integration of reproductive biotechnologies in the context of genomic selection. Workshop at 32nd Scientific Meeting AETE, 2016, Barcelona, Spain. Moderated by Patrice Humblot and Pascal Salvetti. AETE Newsletter, (46):10-11.

Barbat A, Le Mézec P, Ducrocq V, Mattalia S, Fritz S, Boichard D, Ponsart C, Humblot P. 2010. Female fertility in French dairy breeds: current situation and strategies for improvement. J Reprod Dev, 56:S15-S21.

Beaujean N. 2014. Epigenetics, embryo quality and developmental potential. Reprod Fertil Dev, 27:53-62.

Beckers JF, Drion PV, Garbayo JM, Perényi Z, Zarrouk A, Sulon J, Remy B, Szenci O. 1999. Pregnancy associated glycoproteins in ruminants: inactive members of the aspartic proteinase family. Acta Vet Hung, 47:461-469.

Bedere N, Disenhaus C, Ducrocq V, Leurent-Colette S, Delaby L. 2017. Ability of dairy cows to ensure pregnancy according to breed and genetic merit for production traits under contrasted pasture-based systems. J Dairy Sci, 100:2812-2827.

Bogliotti YS, Wub J, Vilarinoa M, Okamurad D, Sotoa DA, Zhonge C, Sakuraib M, Vilar Sampaioa R, Suzukie K, Izpisua Belmontee JC, Rossa PJ. 2018. Efficient derivation of stable primed pluripotent embryonic stem cells from bovine blastocysts. Proc Natl Acad Sci USA, 115:2090-2095.

Boichard D, Manfredi E. 1994. Genetic analysis of conception rate in French Holstein dairy cattle. Acta Agric Scand Sect A, 44:138-145.

Bousquet D, Bouchard E, Du Tremblay B. 2004. Decreasing fertility in dairy cows, myth or reality? In: Proceedings of the 23th World Buiatrics Congress, 2004, Québec, Canada. Quebec:IVIS/WBC. 6 pp.

Brinster RL, Avarbock MR. 1994. Germline transmission of donor haplotype following spermatogonial transplantation. Proc Natl Acad Sci, USA, 91:11303-11307.

Britt JH, Cushman RA, Dechow CD, Dobson H, Humblot P, Hutjens MF, Jones GA, Ruegg PS, Sheldon IM, Stevenson JS. 2018. Invited review: Learning from the future - A vision for dairy farms and cows in 2067. J Dairy Sci, 101:3722-3741.

Butler JE, Hamilton WC, Sasser RG, Ruder C, Hass GM, Williams RJ. 1982. Detection and partial characterization of two bovine pregnancy specific proteins. Biol Reprod, 26:925-933.

Chankeaw W, Lignier S, Raliou M, Ntallaris T, Richard C, Guo Y, Sandra O, Andersson G, Humblot P, Charpigny G. 2018. Specific impacts of mild feed restriction on gene expression of endometrial luminal, glandular and stromal cells in postpartum dairy dows. Reprod Fertil Dev, 30:196. (Abstract).

Chanrot M, Blomqvist G, Guo Y, Ullman K, Juremalm M, Bage R, Donofrio G, Valarcher JF, Humblot P. 2017a. Bovine herpes virus type 4 alters TNF-a and IL-8 profiles and impairs the survival of bovine endometrial epithelial cells. Reprod Biol, 17:225-232.

Chanrot M, Guo Y, Dalin AM, Persson E, Båge R, Svensson A, Gustafsson H, Humblot P. 2017b. Dose related effects of LPS on endometrial epithelial cell populations from dioestrus cows. Anim Reprod Sci, 177:12-24.

Cheng Z, Chauhan L, Barry AT, Abudureyimu A, Oguejiofor CF, Chen X, Wathes DC. 2017. Acute bovine viral diarrhea virus infection inhibits expression of interferon tau-stimulated genes in bovine endometrium. Biol Reprod, 96:1142-1153.

Chupin D, Deletang F, Petit M, Pelot J, Le Provost F, Ortavant R, Parez M, Mauléon P. 1974. Use of progestagens in subcutaneous implants for the control of sexual cycles in the cow. Ann Biol Anim Biochim Biophys, 14:27-39.

Colleau JJ, Sargolzaei M. 2011. MIM: an indirect method to assess inbreeding and coancestry in large incomplete pedigrees of selected dairy cattle. J Anim Breed Genet, 128:163-173.

Colleau JJ, Palhière I, Rodríguez-Ramilo ST, Legarra A. 2017. A fast indirect method to compute functions of genomic relationships concerning genotyped and ungenotyped individuals, for diversity management. Genet Sel Evol, 49:87. doi: 10.1186/s12711-017-0363-9.

Coyral-Castel S, Ramé C, Monniaux D, Fréret S, Fabre-Nys C, Fritz S, Monget P, Dupont J. 2011. Ovarian parameters and fertility of dairy cows selected for one QTL located on BTA3. Theriogenology, 75:1239-1250.

Deletang F. 1975. Synchronisation of oestrus in cattle using a progestagen (SC 21,009) and a synthetic analogue of prostaglandin F2alpha (cloprostenol). Vet Rec, 97:453-454.

Diez C, Heyman Y, Le Bourhis D, Guyader-Joly C, Degrouard J, Renard JP. 2001. Delipidating in vitroproduced bovine zygotes: effect on further development and consequences for freezability. Theriogenology, 55:923-936.

Diskin MG, Murphy JJ, Sreenan JM. 2006. Embryo survival in dairy cows managed under pastoral conditions. Anim Reprod Sci, 96:297-311.

Dobson H, Rowan TG, Kippax IS, Humblot P. 1993. Assessment of fetal number, and fetal and placental viability throughout pregnancy in cattle. Theriogenology, 40:411-425.

Doherty R, Whiston R, Cormican P, Finlay EK, Couldrey C, Brady C, O'Farrelly C, Meade KG. 2016. The CD4(+) T cell methylome contributes to a distinct CD4(+) T cell transcriptional signature in Mycobacterium bovis-infected cattle. Sci Rep, 6:31014. doi: 10.1038/srep31014.

Druet T, Fritz S, Sellem E, Basso B, Gérard O, Salas-Cortes L, Humblot P, Druart X, Eggen A. 2009. Estimation of genetic parameters and genome scan for 15 semen characteristics traits of Holstein bulls. J Anim Breed Genet, 126:269-277.

Ducrocq V, Gion A, Druet T. 2008. Genetic correlations between production, type and functional traits in three French dairy cattle breeds. In: Proceedings of the 59th EAAP Annual meeting, Vilnius, Lituania. Vilnius: EAAP. Sect. 35, abstr. 269.

Fazeli A, Holt WV. 2017. Introduction: a brief guide to the periconception environment. Adv Exp Med Biol, 1014:1-14. doi: 10.1007/978-3-319-62414-3_1.

Foote RH. 1970. Inheritance of fertility, facts opinion and speculations. J. Dairy Sci, 53:936-944.

Freret S, Ficheux C, Jeanguyot N, Joly C, Ponter A, Ponsart C, Grimard B, Humblot P. 2004. Body weight gain variation, hormonal and metabolic status and in vitro embryo production in superovulated dairy heifers. Reprod Fertil Dev, 16:254-254.

Freret S, Grimard B, Ponter AA, Joly C, Ponsart C, Humblot P. 2006. Reduction of body-weight gain enhances in vitro embryo production in overfed superovulated dairy heifers. Reproduction, 131:783- 794.

Galli C. 2017. Achievements and unmet promises of assisted reproduction technologies in large animals: a personal perspective. In Proceedings 33th AETE Scientific Meeting; 2017, Bath, UK. Paris: AETE. pp 9- 32.

Gamarra G, Ponsart C, Lacaze S, Le Guienne B, Humblot P, Deloche MC, Monniaux D, Ponter AA. 2015. Dietary propylene glycol and in vitro embryo production after ovum pick-up in heifers with different anti-Müllerian hormone profiles. Reprod Fertil Dev, 27:1249-1261.

Gamarra G, Ponsart C, Lacaze S, Nuttinck F, Cordova A, Mermillod P, Marquant-Le Guienne B, Monniaux D, Humblot P, Ponter AA. 2018. Oral propylene glycol modifies follicular fluid and gene expression profiles in cumulus-oocyte complexes and embryos in feed-restricted heifers. Reprod Fertil Dev, 30:417-429.

Gao N, Martini JWR, Zhang Z, Yuan X, Zhang H, Simianer H, Li J. 2017. Incorporating gene annotation into genomic prediction of complex phenotypes. Genetics, 207:489-501.

Garnsworthy PC, Fouladi-Nashta AA, Mann GE, Sinclair KD, Webb R. 2009. Effect of dietary-induced changes in plasma insulin concentrations during the early post partum period on pregnancy rate in dairy cows. Reproduction, 137:759-768.

Ghidoni I, Chlapanidas T, Bucco M, Crovato F, Marazzi M, Vigo D, Torre ML, Faustini M. 2008. Alginate cell encapsulation: new advances in reproduction and cartilage regenerative medicine. Cytotechnology, 58:49-56.

Giebel B, Kordelas L, Börger V. 2017. Clinical potential of mesenchymal stem/stromal cell-derived extracellular vesicles. Stem Cell Investig, 4:84. doi: 10.21037/sci.2017.09.06.

Gonzalez C, Le Bourhis D, Guyader Joly C, Moulin B, Heyman Y, Humblot P. 2008. Pregnancy rates after single direct transfer of biopsed frozen-thawed bovine embryos according to quality. Proceedings of the 24th AETE, 2008, abstract 158.

Grimard B, Humblot P, Ponter AA, Mialot JP, Sauvant D, Thibier M. 1995. Influence of postpartum energy restriction on energy status, plasma LH and oestradiol secretion and follicular development in suckled beef cows. J Reprod Fertil, 104:173-179.

Grimard B, Humblot P, Mialot JP, Jeanguyot N, Sauvant D, Thibier M. 1997. Absence of response to oestrus induction and synchronization treatment is related to lipid mobilization in suckled beef cows. Reprod Nutr Dev, 37:129-140

Grimard B, Freret S, Chevallier A, Pinto A, Ponsart C, Humblot P. 2006. Genetic and environmental factors influencing first service conception rate and late embryonic/foetal mortality in low fertility dairy herds. Anim Reprod Sci, 91:31-44.

Grimard B, Le Mezec P, Bidan F, Journeaux L, Salvetti P. 2018. Insemination en élevage bovin en France: nouveau paysage, nouvelles pratiques et marges de progrès. Le Point Vétérinaire, in press.

Guillette LJ Jr, Parrott BB, Nilsson E, Haque MM, Skinner MK. 2016. Epigenetic programming alterations in alligators from environmentally contaminated lakes. Gen Comp Endocrinol, 238:4-12.

Guo Y, Jahmat N, Van Shaik T, Chanrot M, Valarcher JF, Charpigny G, Bongcam-Rudloff E, Andersson G, Humblot P. 2016. Changes in gene expression following exposure of bovine endometrial epithelial cells (BEEC) to escherichia coli LPS; their possible effect on implantation. Reprod Fertil Dev, 29:170-171. (Abstract)

Guyader-Joly C, Guérin P, Renard JP, Guillaud J, Ponchon S, Ménézo Y. 1998. Precursors of taurine in female genital tract: effects on developmental capacity of bovine embryo produced in vitro. Amino Acids, 15:27-42.

Guyader-Joly C, Ponchon S, Durand M, Heyman Y, Renard JP, Ménézo Y. 1999. Effect of lecithin on in vitro and in vivo survival of in vitro produced bovine blastocysts after cryopreservation. Theriogenology, 52:1193-202.

Guyader-Joly C, Ponchon S, Gonzalez C, MarquantLe GuienneB, Clément L, Dalbiès-Tran R, Mermillod P, Humblot P. 2007. Identification of contrasted phenotypes in the bovine from repeated in vivo and in vitro embryo production following superovulation. Reprod Fertil Dev, 20:131-132. (Abstract).

Guyader-Joly C, Gonzalez C, Le Bourhis D, Moulin B, Heyman Y, Humblot P. 2008. Pregnancy rates after single direct transfer of biopsied frozen–thawed bovine embryos according to quality. Reprod Fertil Dev, 21:167. (Abstract).

Haig D. 2007. Weismann Rules! OK? Epigenetics and the Lamarckian temptation. Biol Philos, 22:415-428 Holm P, Booth PJ, Schmidt MH, Greve T, Callesen H. 1999. High bovine blastocyst development in a static in vitro production system using SOFaa medium supplemented with sodium citrate and myo-inositol with or without serum-proteins. Theriogenology, 52:683-700.

Holm P, Booth PJ, Callesen H. 2002. Kinetics of early in vitro development of bovine in vivoand in vitro derived zygotes produced and/or cultured in chemically defined or serum-containing media. Reproduction, 123:553-565.

Humblot P, Thibier M. 1980. Progesterone monitoring of anestrous dairy cows and subsequent treatment with a prostaglandin F2 alpha analog or gonadotropinreleasing hormone. Am J Vet Res, 41:1762-1766.

Humblot P, Thibier M. 1981. Utilisation de schémas thérapeutiques dans un programme de contrôle de l'infécondité dans un troupeau de vaches laitières. Rec Med Vet, 157:91-104.

Humblot P, Dalla Porta MA. 1984. Effect of conceptus removal and intrauterine administrations of conceptus tissue on luteal function in the cow. Reprod Nutr Dev, 24(5A):529-541.

Humblot P, Denis JB. 1986. Sire effects on cow fertility and late embryonic mortality in the Montbeliard breed. Livest Prod Sci, 14:139-148.

Humblot P, Camous S, Martal J, Charlery J, Jeanguyot N, Thibier M, Sasser RG. 1988. Pregnancy specific protein B, progesterone concentrations and embryonic mortality during early pregnancy in dairy cows. J Reprod Fertil, 83:215-223.

Humblot P, Decoux G, Dhorne T. 1991. Effects of the sire and district of AI on cow fertility. Reprod Domest Anim, 26:225-234.

Humblot P, Grimard B, Ribon O, Khireddine B, Dervishi V, Thibier M. 1996. Sources of variation of post-partum cyclicity, ovulation and pregnancy rates in primiparous charolais cows treated with Norgestomet implants and PMSG. Theriogenology, 46:1085-1096.

Humblot P, Negrao S, Nibart M. 1998. Effects of high energy supply and metabolic status on superovulatory response and embryo production in dairy heifers. Theriogenology, 49:378. (Abstract).

Humblot P. 2001. Use of pregnancy specific proteins and progesterone assays to monitor pregnancy and determine the timing, frequencies and sources of embryonic mortality in ruminants. Theriogenology, 56:1417-1433.

Humblot P, Holm P, Lonergan P, Wrenzycki C, Lequarré AS, Joly CG, Herrmann D, Lopes A, Rizos D, Niemann H, Callesen H. 2005. Effect of stage of follicular growth during superovulation on developmental competence of bovine oocytes. Theriogenology, 63:1149-1166.

Humblot P, Grimard B, Freret S, Charpigny G, Ponter AA, Seegers H, Ponsart C. 2008. Impact of energy balance on metabolic changes and reproductive tissues; consequences for ovarian activity and fertility in dairy and beef cattle. In: Garnsworthy PC, Wiseman J (Ed.). Recent Advances in Animal Nutrition. Nottingham, UK: Nottingham University Press.p. 1-14.

Humblot P, Le Bourhis D, Fritz S, Colleau JJ, Gonzalez C, Guyader Joly C, Malafosse A, Heyman Y, Amigues Y, Tissier M, Ponsart C. 2010. Reproductive technologies and genomic selection in cattle. Vet Med Int, 2010:192787. doi: 10.4061/2010/192787.

Humblot P. 2011. Reproductive technologies and epigenetics their implications for genomic selection in cattle. Acta Sci Vet, 39(suppl. 1):S253-262.

Hwang I. 2013. Cell-cell communication via extracellular membrane vesicles and its role in the immune response. Mol Cells, 36:105-111.

Jhamat N, Guo Y, Niazi A, Ivanova E, Kelsey G, Bongcam-Rudloff E, Andersson G, Humblot P. 2016. Identification of differentially methylated regions in the genome of bovine endometrial epithelial cells (BEEC) challenged by E. coli LPS and its effect on transcription. In: Proceedings of the COST Epiconcept Conference, 2016, Giardini-Naxos, Italy. Milan: University of Milan, CoST. Abstr. 32, pp. 41.

Jenko J, Gorjanc G, Cleveland M, Varshney R, Whitelaw C, Woolliams J, Hickey J. 2015. Potential of promotion of alleles by genome editing to improve quantitative traits in livestock breeding programs. Genet Sel Evol, 47:55. doi: 10.1186/s12711-015-0135-3.

Lacaze S, Ponsart C, Discala D, Richet L, Valadier A, Pailhous C, Humblot P. 2008. Use of embryo sexing and MOET in Aubrac cows to save the dairy genetic type. In: Proceedings of the 24th Scientific Meeting AETE, 2008; Pau, France. Pau: AETE. pp. 182. (Abstract).

Laskowski D, Humblot P, Sirard MA, Sjunnesson Y, Jhamat N, Båge R, Andersson G. 2018. DNA methylation pattern of bovine blastocysts associated to hyperinsulinemia in vitro. Mol Reprod Dev. doi: 10.1002/mrd.22995.

Le Bourhis D, Amigues Y, Charreaux F, Lacaze S, Tissier M, Guyader-Joly C, Mervant G, Moulin B, Vignon X, Gonzalez C, Humblot P. 2008. Embryo genotyping from in vivo biopsied bovine embryos after whole genome amplification. Reprod Fertil Dev, 21:192-192. (Abstract).

Le Bourhis D, Mullaart E, Humblot P, Coppieters D, Ponsart C. 2010. Bovine embryo genotyping using a 50k single nucleotide polymorphism chip. Reprod Fertil Dev, 23:197. (Abstract).

Le Mezec P. 2017. Fertilité des principales races laitières: Bilan 199-2015. Paris: Idele Ed. 45 pp.

Le Mezec P. 2018. Statistiques semence sexée. Available on http:/idele.fr/no_cache/recherché/publication/idelesolr/r ecommends/statistique-semence-sexee.html.

Ledoux D, Ponsart C, Grimard B, Gatien J, Deloche MC, Fritz S, Lefebvre R, Humblot P. 2015. Sire effect on early and late embryonic death in French Holstein cattle. Animal, 9:766-774.

Lefebvre R, Fritz S, Ledoux D, Gatien J, Genestout J, Rossignol MN, Grimard B, Boichard D, Humblot P, Ponsart C. 2011. GENIFER: cartographie fine et effets de QTL de fertilité en race bovine Holstein. Rencontres Rech Rumin, 18:415. (Abstract).

Lequarre AS, Vigneron C, Ribaucour F, Holm P, Donnay I, Dalbiès-Tran R, Callesen H, Mermillod P. 2005. Influence of antral follicle size on oocyte characteristics and embryo development in the bovine. Theriogenology. 63:841-859.

Lonergan P, Khatir H, Piumi F, Rieger D, Humblot P, Boland MP. 1999. Effect of time interval from insemination to first cleavage on the developmental characteristics, sex ratio and pregnancy rate after transfer of bovine embryos. J Reprod Fertil, 117:159- 167.

Lonergan P. 2004. Overall bovine embryo transfer activityin Europe in 2003. In: 20th Annual Meeting AETE, 2004, Lyon, France. Lyon: AETE. pp.72-74.

Lopes RF, Forell F, Oliveira AT, Rodrigues JL. 2001. Splitting and biopsy for bovine embryo sexing under field conditions. Theriogenology, 56:1383-1392.

Lucy MC. 2001. Reproductive losses in dairy cattle: where it will end? J Dairy Sci, 84:1277-1293.

Maijala K. 1976. Possibilities for improving fertility in cattle by selection. World Rev Anim Prod, 12:69-76.

Marquant-Le Guienne B, Humblot P, Thibier M, Thibault C. 1990. Evaluation of bull semen fertility by homologous in vitro fertilization tests. Reprod Nutr Dev, 30:259-266.

Marquant-Le Guienne B, Humblot P. 1998. Practical measures to improve in vitro blastocyst production in the bovine. Theriogenology, 49:3-11.

Martal J, Lacroix MC, Loudes C, Saunier M, Wintenberger-Torrès S. 1979. Trophoblastin, an antiluteolytic protein present in early pregnancy in sheep. J Reprod Fertil, 56:63-73.

Martin AD, Afseth NK, Kohler A, Randby Å, Eknæs M, Waldmann A, Dørum G 2nd, Måge I, Reksen O. 2015. The relationship between fatty acid profiles in milk identified by Fourier transform infrared spectroscopy and onset of luteal activity in Norwegian dairy cattle. J Dairy Sci, 98:5374-5384.

Mellouk N, Rame C, Touze JL, Briant E, Ma L, Guillaume D, Lomet D, Caraty A, Ntallaris T, Humblot P, Dupont J. 2017. Involvment of plasma adipokines in metabolic and reproductive parameters in Holstein dairy cows fed with diets with differing energy levels. J Dairy Sci, 100:8518-8533.

Menck MC, Guyader-Joly C, Peynot N, Le Bourhis D, Lobo RB, Renard JP, Heyman Y. 1997. Beneficial effects of Vero cells for developing IVF bovine eggs in two different coculture systems. Reprod Nutr Dev, 37:141-150.

Merton S. 2005. Overall bovine embryo transfer activityin Europe in 2004. In: 21st Annual Meeting AETE, 2005, Keszthely, Hungary. Keszthely: AETE.pp. 73-75.

Meuwissen THE, Goddard ME. 1999. Marker assisted estimation of breeding values when marker information is missing on many animals. Genet Sel Evol, 31:375- 394.

Morrell J. 2016. Practical applications of sperm selection techniques for improving reproductive efficiency. In: Proceedings 32th AETE Annual Meeting, 2016, Barcelona, Spain. Barcelona; AETE. pp 101-115.

Morrell J, Humblot P. 2016. Animal reproduction technologies: future perspectives. J Agric Sci Technol, 6:301-313.

Morrell J, Willforss J, Resjö S, Levander F, Hallap T, Andreasson E, De Koning DJ, Humblot P. 2018. Identification of markers of bull fertility in seminal plasma (SP) from protein patterns. In: Proceedings BSAS Bull Fertility Conference 2018: Bull fertility - Theory to practice, 2018, Westport, Ireland. Midlothian, UK: BSAS. (Abstract).

Mossa F, Jimenez-Krassel F, Scheetz D, WeberNielsen M, Evans ACO, Ireland JJ. 2017. Antimüllerian hormone (AMH) and fertility management in agricultural species. Reproduction, 154:R1-R11. doi: 10.1530/REP-17-0104.

Muñoz M, Uyar A, Correia E, Díez C, FernandezGonzalez A, Caamaño JN, Martínez-Bello D, Trigal B, Humblot P, Ponsart C, Guyader-Joly C, Carrocera S, Martin D, Marquant Le Guienne B, Seli E, Gomez E. 2014a. Prediction of pregnancy viability in bovine in vitro-produced embryos and recipient plasma with Fourier transform infrared spectroscopy. J Dairy Sci, 97:5497-5507.

Muñoz M, Uyar A, Correia E, Ponsart C, GuyaderJoly C, Martínez-Bello D, Marquant-Le Guienne B, Fernandez-Gonzalez A, Díez C, Caamaño JN, Trigal B, Humblot P, Carrocera S, Martin D, Seli E, Gomez E. 2014b. Metabolomic prediction of pregnancy viability in superovulated cattle embryos and recipients with fourier transform infrared spectroscopy. Biomed Res Int, 608579. doi: 10.1155/2014/608579.

Nibart M, Humblot P. 1997a. Utilisation des hormones gonadotropes hypophysaires chez les bovins. In : Combarnous Y, Volland-Nail P. (Ed.). Les gonadotropines. Paris: INRA. pp. 377-394.

Nibart M, Humblot P. 1997b. Pregnancy rates following direct transfer of glycerol sucrose or ethylene glycol cryopreserved bovine embryos. Theriogenology, 47:371. (Abstract).

Nibart M, Marquant-Le Guienne B, Humblot P, Guerin B. 1997. The application of new reproductive technologies in France. Arq Fac Vet UFRGS, 25(suppl. 1):21-35.

Northey DL, French LR. 1980. Effect of embryo removal and intrauterine infusion of embryonic homogenates on the lifespan of the bovine corpus luteum. J Anim Sci, 50:298-302

Ntallaris T, Humblot P, Båge R, Sjunnesson Y, Dupont J, Berglund B. 2017. Effect of energy balance profiles on metabolic and reproductive response in Holstein and Swedish Red cows. Theriogenology, 90:276-283.

Oatley JM. 2018. Recent advances for spermatogonial stem cell transplantation in livestock. Reprod Fertil Dev, 30:44-49.

Oguejiofor CF, Cheng Z, Abudureyimu A, Anstaett OL, Brownlie J, Fouladi-Nashta AA, Wathes DC. 2015a Global transcriptomic profiling of bovine endometrial immune response in vitro. II. Effect of bovine viral diarrhea virus on the endometrial response to lipopolysaccharide. Biol Reprod, 93(4):101. doi: 10.1095/biolreprod.115.128876.

Oguejiofor CF, Cheng Z, Abudureyimu A, FouladiNashta AA, Wathes DC. 2015b. Global transcriptomic profiling of bovine endometrial immune response in vitro. I. Effect of lipopolysaccharide on innate immunity. Biol Reprod. 93(4):100. doi: 10.1095/biolreprod.115.128868.

Ord J, Fazeli A, Watt PJ. 2017. Long-term effects of the periconception period on embryo epigenetic profile and phenotype: the role of stress and how this effect is mediated. Adv Exp Med Biol, 1014:117-135.

Pennetier S, Uzbekova S, Guyader-Joly C, Humblot P, Mermillod P, Dalbies-Tran R. 2005. Genes preferentially expressed in bovine oocytes revealed by subtractive and suppressive hybridization. Biol Reprod, 73:713-720.

Perényi ZS, Szenci O, Drion PV, Banga-Mboko H, Sousa NM, El Amiri B, Beckers JF. 2002. Aspartic proteinase members secreted by the ruminant placenta: specificity of three radioimmunoassay systems for the measurement of pregnancy-associated glycoproteins. Reprod Domest Anim, 37:324-349.

Piras C, Guo Y, Soggiu A, Chanrot M, Greco V, Urbani A, Charpigny G, Bonizzi L, Roncada P, Humblot P. 2017. Changes in protein expression profiles in bovine endometrial epithelial cells exposed to E. coli LPS challenge. Mol Biosyst, 13:392-405.

Ponsart C, Marquant Leguienne B, Humblot P. 2004. Evolution and future trends for use of embryo based biotechnologies in the bovine. In: Proceedings 11th Rencontre Recherche Ruminants (3R), 2004, Paris, France. Paris: INRA. pp. 361-368.

Ponsart C, Salas Cortes L, Jeanguyot N, Humblot P. 2008. Le sexage des embryons a le vent en poupe. Bulletin Technique de l’Insémination Artificielle, 129: 30-31.

Rico C, Fabre S, Médigue C, di Clemente N, Clément F, Bontoux M, Touzé JL, Dupont M, Briant E, Rémy B, Beckers JF, Monniaux D. 2009. Antimullerian hormone is an endocrine marker of ovarian gonadotropin-responsive follicles and can help to predict superovulatory responses in the cow. Biol Reprod, 80:50-59.

Ricci A, Carvalho PD, Amundson MC, Fourdraine RH, Vincenti L, Fricke PM. 2015. Factors associated with pregnancy-associated glycoprotein (PAG) levels in plasma and milk of Holstein cows during early pregnancy and their effect on the accuracy of pregnancy diagnosis. J Dairy Sci, 98:2502-2514.

Rickard JP, Leahy T, Soleilhavoup C, Tsikis G, Labas V, Harichaux G, Lynch GW, Druart X, de Graaf SP. 2015. The identification of proteomic markers of sperm freezing resilience in ram seminal plasma. J Proteomics, 126:303-311.

Rizos D, Maillo V, Sánchez-Calabuig MJ, Lonergan P. 2017. The consequences of maternal-embryonic cross talk during the periconception period on subsequent embryonic development. Adv Exp Med Biol, 1014:69-86.

Robertson SA. 2005. Seminal plasma and male factor signalling in the female reproductive tract. Cell Tissue Res, 322:43-52.

Royal M, Darwash AO, Flint APF, Webb R, Wooliams JA, Lamming GE. 2000. Declining fertility in dairy cattle: changes in traditional and endocrine parameters for fertility. Anim Sci, 70:487-501.

Salilew-Wondim D, Ibrahim S, Gebremedhn S, Tesfaye D, Heppelmann M, Bollwein H, Pfarrer C, Tholen E, Neuhoff C, Schellander K, Hoelker M. 2016. Clinical and subclinical endometritis induced alterations in bovine endometrial transcriptome and miRNome profile. BMC Genomics, 17:218. doi: 10.1186/s12864-016-2513-9.

Salvaing J, Peynot N, Bedhane MN, Veniel S, Pellier E, Boulesteix C, Beaujean N, Daniel N, Duranthon V. 2016. Assessment of 'one-step' versus 'sequential'embryo culture conditions through embryonic genome methylation and hydroxymethylation changes. Hum Reprod, 31:2471-2483.

Sartori R, Prata AB, Figuieiredo ACS, Sanches BV, Pontes GCS, Viana JHM, Pontes JH, Vasconcelos JLM, Pereira MHC, Dode MAN, Monteiro PLJ, Baruselli PS. 2016. Update and overview on assited reproductive technologies (ARTs) in Brazil. Anim Reprod, 13:300-312.

Sasser RG, Ruder CA, Ivan, KA, Butler JE, Hamilton WC. 1986. Detection of pregnancy by radioimmunoassay of a novel pregnancy specific protein in serum of cows and a profile of serum concentrations during gestation. Biol Reprod, 35:936-942.

Segars JH , Aagaard-Tillery KM. 2009. Epigenetics in Reproduction. Semin Reprod Med, 27:349-350.

Sepulveda-Rincon LP, Solanas Edel L, SerranoRevuelta E, Ruddick L, Maalouf WE, Beaujean N. 2016. Early epigenetic reprogramming in fertilized, cloned, and parthenogenetic embryos. Theriogenology. 86:91-98.

Shojaei Saadi HA, Vigneault C, Sargolzaei M, Gagné D, Fournier É, de Montera B, Chesnais J, Blondin P, Robert C. 2014. Impact of whole-genome amplification on the reliability of pre-transfer cattle embryo breeding value estimates. BMC Genomics, 15:889. doi: 10.1186/1471-2164-15-889

Simianer H, Pook T, Schlather M. 2018. Turning the PAGE - the potential of genome editing in breeding for complex traits revisited. In: Proceedings of the 11st World Congress on Genetics Applied to Livestock Production, 2018, Auckland, New Zealand. Auckland: WCGALP. pp. 190-194.

Sirard MA. 2001. Resumption of meiosis: mechanism involved in meiotic progression and its relation with developmental competence. Theriogenology, 55:1241- 1254.

Sirard MA, Richard F, Blondin P, Robert C. 2006. Contribution of the oocyte to embryo quality. Theriogenology, 65:126-136. Review Soleilhavoup C, Tsikis G, Labas V, Harichaux G, Kohnke PL, Dacheux JL, Guérin Y, Gatti JL, de Graaf SP, Druart X. 2014. Ram seminal plasma proteome and its impact on liquid preservation of spermatozoa. J Proteomics, 109:245-260. doi: 10.1016/j.jprot.2014.07.007.

Standerholen FB, Waterhouse KE, Larsgard AG, Garmo RT, Myromslien FD, Sunde J, Ropstad E, Klinkenberg G, Kommisrud E. 2015. Use of immobilized cryopreserved bovine semen in a blind artificial insemination trial. Theriogenology, 84:413-420.

Thatcher WW, Hansen PJ, Gross TS, Helmer SD, Plante C, Bazer FW. 1989. Antiluteolytic effects of bovine trophoblast protein-1. J Reprod Fertil Suppl, 37:91-99.

Thibier M, Petit M, Humblot P. 1977. Use of progesterone concentrations in peripheral plasma or milk in cattle herd management. In: Sreenan JM (Ed.). Control of reproduction in the cow. New York, NY: Springer. pp. 576-595. (Current Topics in Veterinary Medicine, 1).

Thibier M, Gouffe D, Jean O, Valognes J, Daunizeau A, Humblot P. 1985. Enhancing the rate of recovery and quality of the embryos in repeat breeding cows by using a GnRH analogue injection at mid-luteal phase prior to breeding. Theriogenology, 24:725-736.

Thibier M, Nibart M. 1995. The sexing of bovine embryos in the field. Theriogenology, 43:71-80 Thibier M. 2001. Identified and unidentified challenges for reproductive biotechnologies regarding infectious diseases in animal and public health. Theriogenology, 56:1465-1481.

Thibier M. 2011. Embryo transfer: a comparative biosecurity advantage in international movements of germplasm. Rev Sci Tech, 30:177-188.

Touzard E, Reinaud P, Dubois O, Guyader-Joly C, Humblot P, Ponsart C, Charpigny G. 2013. Specific expression patterns and cell distribution of ancient and modern PAG in bovine placenta during pregnancy. Reproduction, 146:347-362.

Valour D, Hue I, Degrelle SA, Déjean S, Marot G, Dubois O, Germain G, Humblot P, Ponter AA, Charpigny G, Grimard B. 2013. Preand post-partum mild underfeeding influences gene expression in the reproductive tract of cyclic dairy cows. Reprod Domest Anim, 48:484-499.

Van Soom A, Fazeli A. 2015. Epigenetics and periconception environment: an introduction. Reprod Fertil Dev, 27(5):iii-v.

Vajta G, Holm P, Greve T, Callesen H. 1997. Survival and development of bovine blastocysts produced in vitro after assisted hatching, vitrification and in-straw direct rehydration. J Reprod Fertil, 111:65- 70.

Vajta G, Rindom N, Peura TT, Holm P, Greve T, Callesen H. 1999. The effect of media, serum and temperature on in vitro survival of bovine blastocysts after Open Pulled Straw (OPS) vitrification. Theriogenology, 52:939-948.

Wallace JM, Aitken RP, Cheyne MA, Humblot P. 1997. Pregnancy-specific protein B and progesterone concentrations in relation to nutritional regimen, placental mass and pregnacy outcome in growing adolescent ewes carrying singleton fetuses. J Reprod Fertil, 109:53-58.

Wathes DC, Cheng Z, Chowdhury W, Fenwick MA, Fitzpatrick R, Morris DG, Patton J, Murphy JJ. 2009. Negative energy balance alters global gene expression and immune responses in the uterus of postpartum dairy cows. Physiol Genomics, 39:1-13.

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