Animal Reproduction (AR)
https://www.animal-reproduction.org/article/5b5a607ef7783717068b47c1
Animal Reproduction (AR)
Conference Paper

Testis cord morphogenesis: determination, establishment, and maintenance

C-F. Liu, D.R. Archambeault, H H-C. Yao

Downloads: 0
Views: 571

Abstract

Since the discovery of the testis-determining gene SRY in the early 1990s, rapid progress has been made in illuminating the genetic pathways for testis cord morphogenesis. Research on fetal testis cord development has largely focused on two key areas – testis determination and testis cord establishment. In the first of these events, expression of SRY in the XY gonad triggers a signaling cascade, which establishes the Sertoli cell lineage and thus secures testis identity. The second event, testis cord establishment, relies upon expansion of the Sertoli cell population as well as the migration of cells from the mesonephros. In this review, we aim to discuss these two stages of testis cord formation as well as suggest the existence of a third phase in this fascinating process – the need for further maintenance of the testis cords during the period between testis cord establishment and birth

Keywords

testis development, testis determination, Sertoli cells, mouse
5b5a607ef7783717068b47c1 animreprod Articles
Links & Downloads

Anim Reprod

Share this page
Page Sections